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Isao Kinoyama Selected Research

sepantronium

9/2012Sepantronium bromide (YM155) induces disruption of the ILF3/p54(nrb) complex, which is required for survivin expression.
7/2012Interleukin enhancer-binding factor 3/NF110 is a target of YM155, a suppressant of survivin.
6/2011YM155, a novel survivin suppressant, enhances taxane-induced apoptosis and tumor regression in a human Calu 6 lung cancer xenograft model.
3/2011Broad spectrum and potent antitumor activities of YM155, a novel small-molecule survivin suppressant, in a wide variety of human cancer cell lines and xenograft models.
10/2010[Survivin supressant: a promising target for cancer therapy and pharmacological profiles of YM155].
9/2007YM155, a novel small-molecule survivin suppressant, induces regression of established human hormone-refractory prostate tumor xenografts.

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Isao Kinoyama Research Topics

Disease

6Neoplasms (Cancer)
09/2012 - 09/2007
3Prostatic Neoplasms (Prostate Cancer)
03/2011 - 04/2005
2Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
06/2011 - 03/2011
2Body Weight (Weight, Body)
06/2011 - 09/2007
1Paralysis (Palsy)
11/2011
1Botulism
11/2011
1Lung Neoplasms (Lung Cancer)
06/2011
1Non-Hodgkin Lymphoma (Lymphosarcoma)
03/2011
1Melanoma (Melanoma, Malignant)
03/2011
1Urinary Bladder Neoplasms (Bladder Cancer)
03/2011
1Ovarian Neoplasms (Ovarian Cancer)
03/2011
1Sarcoma (Soft Tissue Sarcoma)
03/2011
1Breast Neoplasms (Breast Cancer)
03/2011
1Leukemia
03/2011

Drug/Important Bio-Agent (IBA)

6SurvivinIBA
09/2012 - 09/2007
6sepantroniumIBA
09/2012 - 09/2007
2Hormones (Hormone)IBA
03/2011 - 09/2007
1Botulinum Toxins (Botulinum Toxin)IBA
11/2011
1taxaneIBA
06/2011
1Docetaxel (Taxotere)FDA Link
06/2011
1bicalutamide (Casodex)FDA LinkGeneric
04/2005

Therapy/Procedure

2Therapeutics
06/2011 - 10/2010